According to Iranian television, Javad left the country on Tuesday for Damascus and is scheduled to meet Syrian President Bashar al-Assad. He will also hold meetings with Foreign Minister Walid al-Moallem and Prime Minister Emad Khamis.
ISNA said Zarif would follow the most important issues related to the bilateral relations and coordinate positions on the most important regional and international issues.
The Syrian regime's ambassador in Tehran, Adnan Mahmoud, called the Iranian foreign minister and informed him at the invitation of Syrian President Bashar al-Assad to visit Damascus.
The phone call came after Iranian Foreign Minister Mohammad Javad Zarif and Syrian Foreign Minister Walid al-Moallem held talks after Zarif regained his resignation.
Zarif quit his post on February 25 after Bashar al-Assad's visit to Tehran, but did not explain the reasons, but observers interpreted it as a protest against the Iranian leadership's lack of coordination with him about al-Assad's visit.